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 | Seeking existing market solutions targeted towards crawling insects |
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The issue of crawling insects in homes has been an ongoing issue. The popular types of crawling insects causing problems have been ants and cockroaches. The search will focus on existing market solutions targeted towards crawling insects such as ants and cockroaches (other types of crawling insects are in scope i.e., bed bugs). |
 | Seeking technologies to reduce GHGs in all aspects of the supply chain and manufacturing process. |
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PepsiCo is committed to reducing GHG emissions from seed to shelf. We are looking to engage with partners who can assist us in our goal of reducing GHG 20% by 2030 and achieving net-zero emissions by 2050. As new technologies emerge, efficiencies will be gained and PepsiCo aims to remain at the forefront of best practices in the food and beverage industry. PepsiCo is seeking technologies to reduce GHGs in all aspects of the supply chain and manufacturing process. Solutions may be in one or more of the following areas: • Agriculture – sustainable farming and the reduction of GHG intensive fertilizers • Manufacturing – adopting energy efficient manufacturing processes; novel methods for utilizing waste; use of renewable thermal energy at scale • Packaging – alternative packaging materials and formats that reduce GHGs • Distribution – technologies to assist in the efficiency of our company-owned and third party fleet |
| | Seeking natural colors for foods and beverages |
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PepsiCo is evaluating different natural color ingredients and technologies to replace Yellow #5, Yellow #6, Red #40, and Blue #1 for multiple food and beverage brands in order to address consumer demand. Specific challenges are in the Red #40 (food) and Blue #1 (food & beverage) replacers. |
 | Efficient and selective magnetic adsorbent for removal of purine compounds and nucleic acids from liquid matrices |
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New low cost magnetic adsorbents prepared from egg-shell membranes and deep eutectic solvents, which selectively and effectively remove purine compounds and nucleic acids from liquid matrices, such as fermented drinks and/or alcoholic beverages. |
 | In silico platform for targeting protein-protein interaction, pharmacogenomics “COSMOS” |
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The COSMOS method developed by the research team at the Tokyo University of Science (TUS) offers a platform for “personalized drug discovery” based on a novel drug discovery methodology. The concept is to identify an optimal binding peptide that interacts with the active/regulatory site (Hot Spot) of the target drug discovery protein by using in silico methods. |
 | Exon skipping by CRISPR-Cas9 editing for Duchenne muscular dystrophy |
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Background Duchenne muscular dystrophy (DMD) is a rare, severe genetic disease characterized by progressive muscle wasting. It is caused by mutations in DMD gene that prevent the production of the muscle isoform of dystrophin protein. The symptom onset is usually in early childhood and life expectancy is ~30 years. Elevidys is currently the only gene therapy approved for DMD, which is designed to deliver a gene coding for a shorter version of dystrophin. This approach was taken because delivery of the whole DMD gene is challenging as it is the largest human gene. Antisense oligonucleotide medications for exon skipping (exons 45, 51, and 53) to produce a shorter yet functional dystrophin gene have been approved, which require periodic administration. None of the drugs is suitable for all DMD patients. More treatment solutions are urgently needed. |
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